Assistant Scientist 1 (Chromatographic Bioanalysis, Discovery)

Req ID:  182491

Tranent, GB, EH33 2NE

At Charles River, we are passionate about improving the quality of people’s lives. When you join our global family, you will help create healthier lives for millions of patients and their families. 

Charles River employees are innovative thinkers, who are dedicated to continuous learning and improvement. We will empower you with the resources you need to grow and develop in your career. 

As a Charles River employee, you will be part of an industry-leading, customer-focused company at the forefront of drug development. Your skills will play a key role in bringing life-saving therapies to market faster through simpler, quicker, and more digitalized processes. Whether you are in lab operations, finance, IT, sales, or another area, when you work at Charles River, you will be the difference every day for patients across the globe.

Job Summary

We are seeking an Assistant Scientist for our Chromatographic Bioanalysis Department (Discovery) located in Elphinstone, Tranent. 

The primary function of Chromatographic Bioanalysis is to perform quantitative analysis of drugs and/or metabolites in biological samples, usually fluids such as plasma and serum. These samples arise from both preclinical and clinical studies aimed at providing data for the development and registration of pharmaceuticals. 

The main duties of this position will involve the validation and application of analytical methods to quantify the levels of drugs and metabolites in biological fluids.  As an Assistant Scientist you will be fully trained in all aspects of these studies, including sample processing, set-up/operation of analytical systems, primarily HPLC with mass spectrometric detection (LC-MS), and data review and processing (using Watson Laboratory Information Management System), so that you can play a full role in the conduct of bioanalytical studies. 

A working knowledge of sample preparation and chromatographic techniques, including HPLC and/or LC-MS, would be a distinct advantage, though not essential as full training will be given.

The following are responsibilities related to the Assistant Scientist position:
•    Use HPLC with MS detection for quantification of compounds in liquid matrices in support of in-vivo and in-vitro studies
•    Carry out experiments in support of method validation and subsequent routine samples generated within GLP Voluntary, GLP and/or GCP regulatory studies
•    Required to follow out written instructions (standard operating procedures, protocols, analytical procedures) and document details of steps carried out to ensure compliance through recreation of events 
•    Perform technical laboratory activities in support of client studies or procedures
•    Carry out analysis of data for quality and completeness and determines if results are as expected
•    Record data in compliance with company and regulatory policies and standards to meet quality and accuracy requirements 

Profile and Requirements


The minimum qualifications related to the Assistant Scientist role are:
•    A BSc in a Chemistry or related discipline
•    A working knowledge of sample preparation and chromatographic techniques is desirable
•    Good problem solving skills and be able to work to tight deadlines and record data accurately
•    Effective communication skills

The starting salary for this position is £24,876 with enrolment onto our Graduate Progression Scheme.

The successful candidate will be appointed to the starting point of the pay band if they have no relevant experience. In exceptional circumstances, where the candidate has relevant equivalent experience, this will be taken into consideration. 

The closing date for this role is Monday, 22 August, 2022.



About Safety Assessment
Charles River is committed to helping our partners expedite their preclinical drug development with exceptional safety assessment services, state-of-the-art facilities and expert regulatory guidance. From individual specialty toxicology and IND enabling studies to tailored packages and total laboratory support, our deeply experienced team can design and execute programs that anticipate challenges and avoid roadblocks for a smooth, efficient journey to market.  Each year approximately 300 investigational new drug (IND) programs are conducted in our Safety Assessment facilities.

About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increased to $2.62 billion.

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2019.


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