Scientist (Immunology, Cell Biology and Analytical)

Req ID:  97485
Location: 

Portishead, GB, BS20 7AW

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Job Summary

Charles River Laboratories (Portishead) is an immunology and infection specialist CRO that utilizises cutting-edge techniques and in-depth expertise to deliver state-of-the-art cell biology assays. Clients include a broad range of global pharmaceutical and biotechnology companies and Charles River supports them throughout the drug discovery process, from early hit identification through to clinical trials. We are looking to recruit a Scientist to enhance our dynamic Cell Biology and Analytical Services teams on a permanent basis. This opportunity would be ideal for a motivated and pro-active individual that wants to contribute to the success of an ambitious company.   
  
As an aspiring immunologist you will be working across multidisciplinary teams investigating the efficacy of a wide range of therapeutic modalities or solving the molecular and cellular mechanisms underpinning immuno-oncology, autoimmunity, inflammatory disease and neuroinflammation. The core role of this lab-based position will be to design and execute studies to realize the potential of next generation immunotherapies. This will include the characterization and validation of complex immunological assays through the implementation of ex vivo and in vitro models (e.g. immune cell mono/co-cultures, ex vivo phenotypic analysis, genetic/pharmacological intervention, cell engineering and biomarker analyses of early phase clinical trials). A background in or willingness to learn techniques such as IncuCyte, MACS sorting, 18-flow cytometry, Luminex, Nanostring, ELISpot, qPCR, Lentiviral delivery, high content screening and culture of primary cells is essential.  
 


Requirements: 
•    BSc/MSc/PhD with lab experience and a strong understanding of immunology. Experience working within Pharma/Biotech or in a Postdoctoral role within the immunology field would be an advantage 
•    Ambition to discover novel therapeutics through collaboration 
•    Experience with immune cell isolation and cell culture 
•    Track record of  carrying out complex immunological experiments 
•    Well organized and self-motivated to deliver high quality data sets to tight deadlines 
•    Compliance to protocols and all applicable SOPs 
•    Ability to generate clear and concise conclusions from experimental data sets 
•    Experience in disseminating scientific discoveries internally and externally 
•    A clear grasp of the drug discovery process 
•    Critical thinking and problem-solving skills 

About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 350 patents and 80 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.

 

About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

 

With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increased to $2.62 billion.

 

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2019.