Job Overview

Are you ready for a new challenge? 
Join our in vitro Metabolism Team in Den Bosch and take on a role with a wide variety of tasks and responsibilities. At Charles River Laboratories Den Bosch we are currently hiring a: 

Experienced Analytical Chemistry Technician – in vitro Metabolism 

About us:  
At Charles River Laboratories, we help make the world a safer place by studying the behavior of substances before they reach the market. These substances include medicines, (agro)chemicals, and food ingredients, Our Discovery & Environmental Sciences department consists of about 90 talented professionals working on diverse projects for clients worldwide. Characteristic of the work is the great diversity of tests, test substances, customers and collaborations. 

About the team: 
Within the Discovery & Environmental Sciences department, you’ll join our in vitro metabolism section, a dynamic group that investigates how compounds are processed in the body and interact with biological processes. We test these compounds in various studies using in vitro models including hepatocytes, blood and plasma. The chemical analysis of these compounds is performed using mass spectrometry (LC-MS) to quantify them in biological materials. For some studies, we identify unknown metabolites using high-resolution LC-MS instruments, requiring complex scientific problem-solving. 

Our team consists of 9 study directors (scientific project managers) and 13 technicians. We work in an open, informal and flexible culture where collaboration and mutual support are key, and innovation is actively encouraged.  

About your role:   

As an experienced technician, you’ll play a key role in performing a wide range of in vitro metabolism studies.  

You will perform various in vitro metabolism studies from sample pre-treatment, method development, implementation and sample analysis with LC-MS/MS. Next to the study work, you are involved in researching, developing and validating of new study setups. 

You will be working in a recently renovated laboratory (2021) equipped with new state-of-the-art analytical equipment. 

Your profile: 
•    A relevant applied science degree (HBO/HLO) in analytical chemistry or biochemistry 
•    Minimal 2 years’ experience with LC-MS/MS, including method development and validation  
•    Interest in identifying unknown compounds and using data analysis software (e.g., Xcalibur, Compound Discoverer, Empower and Masslynx) 
•    Strong communication skills in Dutch and English. 
•    A hands-on, creative problem-solving attitude. 
•    Proactive, results-driven, and flexible personality. 

Nice to have: 
•    Familiarity with biological test systems or biological materials 
•    Certification to work with radioactive materials 
•    Knowledge of Good Laboratory Practice (GLP)

Job Description

Our offer:  

Working at our organization means working in a dynamic international organization with a modern laboratory and a wide variety of equipment and techniques at your disposal.  

In addition, we offer excellent primary and secondary working conditions including:  
  

•    Ongoing training and support;  
•    29.5 holidays on a full-time basis; 
•    Possibility to purchase 10 additional holidays per year;  
•    Annual one-off 8% holiday pay of your gross annual salary;  
•    Annual one-off payment based on company results;  
•    Travel allowance at €0.23 cents per kilometer with a maximum of €250 net per month or an NS Business Card;  
•    Bicycle (lease) plan;  
•    Collective pension with a own contribution of 2.9%;  
•    Company fitness membership;  
•    The opportunity to play sports with colleagues on our own sports field;  
•    The possibility of a consultation with our in-house ergonomist;  
•    Free fresh fruit every day. 

Education

Physical Requirements