Scientist 2

Req ID #:  87716

Boston, MA, US, 02116

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Job Summary

We are seeking an experienced Scientist 2 for a contract position in a mid-size pharma/biotech company centrally located within the Great Boston biotech hub. The initial term of the position is one year, contract can be renewed on yearly basis, and has the possibility of converting to a permanent position.


The successful candidate for this position will have a strong background in small molecule bioanalysis utilizing LC-MS/MS. Experience with large molecule bioanalysis is a strong plus. Assays are often developed for early stage discovery and the ability to develop novel approaches is essential, thus requiring a solid understanding of the analytical methodology for complex modalities from small molecules to proteins and peptides. This individual will be responsible for scientifically-sound planning and execution of experiments in a timely manner.  The position requires a commitment to the delivery of quality data, colleague interactions, independent hands-on method development and sample analysis.

Successful candidates in this position will:


  • Capable of extraction and analysis of biological samples, including extraction and instrumental analysis as well as data generation, review and presentation. 
  • Strong experience in the bioanalysis of small and large molecules from biological samples, including sample prep and instrumental analysis as well as data generation, review and presentation.
  • Prior experience with other ADME assays such as plasma protein binding and tissue partitioning skills.
  • Excellent interpersonal skills and demonstrated ability to work collaboratively in a team environment with colleagues at various levels.
  • Attention to detail and the ability to critically analyze and verify data prior to data release.
  • Document study data and reports in an accurate, organized and timely manner.
  • Overall excellent organizational skills with attention to details. 
  • Able to trouble shoot instrument issues and preform regular maintenance.


The following are minimum qualifications related to the Scientist 2 position:

Education:  Bachelor's degree (B.S./B.A.)  with emphasis in Biochemistry or an equivalent scientific related discipline. Related Master's degree (M.S./M.A.) preferred. 
Experience:  at least 6 years previous directly related laboratory experience in large molecule bioanalysis by LC/MS/MS with emphasis on siRNA, ASOs, proteins, antibodies and complex modalities.
An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above.
Other:  Exceptional method development and assay troubleshooting skills.  Excellent written and verbal communication skills in a team environment. Able to prioritize work and meet deadlines under minimal direction. Adept in use of standard software including Microsoft® Excel, Word, PowerPoint, etc. and with standard laboratory calculations. Strong proficiency in the use of analytical instrumentation, specifically with AB Sciex LC-MS/MS instruments. Proficiency with Water gTOP and Thermo QE HRMS. Proficiency in the use of BA software including Analyst, Discovery Quant, MultiQuant, and familiar with automation platforms such as Hamilton and multiplexing system.



About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 320 patents and 74 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.


About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.


With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increased to $2.62 billion.


At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2019.


Equal Employment Opportunity


Charles River Laboratories is an Equal Opportunity Employer - M/F/Disabled/Vet.


If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.


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