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Senior Scientist, Mass Spectrometry

Req ID #:  43848

Shrewsbury, MA, US, 01545

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Job Summary

We are seeking an experienced Senior Scientist, Mass Spectrometry in our Biologics group currently located in Woburn, MA but relocating to Shrewsbury, MA in Q2/Q3 of 2019 due to growth.


In this position, the Senior Scientist will be responsible for the development and execution of highly complex method development and structural characterization studies related to the analysis of biotherapeutics using mass spectrometry (MS). Oversee laboratory and scientific staff, assists with maintaining operational readiness, including instrument performance and regulatory compliance. Other responsibilities include functioning independently as the Principal Investigator and technical expert on highly complex studies; develop, perform, and troubleshoot experiments, tests, and procedures within accepted regulatory compliance for the characterization and analysis of biotherapeutics, particularly using HPLC-MS/MS. Generate and finalize protocols for method development and characterization studies; ensure that study protocols are amended in a timely fashion to accurately reflect any changes in scope of work or deliverables. Be the primary contact for planning and execution of Sponsor interactions related to proposal management, research and method development, and for the design, scheduling, conduct and reporting of studies. Efficiently organize and plan study assignments of scientific staff, providing mentoring and technical guidance to resolve analytical challenges in a timely fashion. Review, interpret, analyze, evaluate, and discuss study results with research staff and Sponsor. 


Perform routine testing in techniques such as the following with a degree of reliability, efficiency and accuracy.


    • Peptide Mapping LC-UV-MS/(MS)
    • Intact Molecular Weight Analyses LC-UV-MS
    • SDS PAGE, SPE, HPLC Peak Collection
    • Glycosylation Mapping via LC-MS/MS
    • N- and O- Linked Glycsylation Profiling
    • Proteomics
    • QTOF, Triple Quadrupole, and Orbitrap Platforms
    • Use of Agilent and Thermo MS Software


The following are minimum requirements related to the Senior Scientist Mass Spectrometry position.

  • Bachelor’s degree (B.A./B.S.) or equivalent in Chemistry/Biotechnology or related scientific discipline. M.S. or Ph.D. strongly preferred
  • Minimum seven years of relevant experience within a contract research (CRO), academic or pharmaceutical industry
  • An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above

About Biologics Testing Solutions

With more than 50 years of experience and proven regulatory expertise, the Charles River Biologics group can address challenging projects for biotechnology and pharmaceutical companies worldwide. Offering a variety of services such as contamination and impurity testing, protein characterization, bioassays, viral clearance studies and stability and lot release programs, we support clients throughout the biologic development cycle, from the establishment and characterization of cell banks through preclinical and clinical studies to marketed products. Whether clients need stand-alone services, a unique package of testing, or insourced support, our Biologics group can create a custom solution to suit their needs.  Each year more than 20,000 biologic testing reports are sent each and over 200 licenses products are supported by our biologics testing solutions team.


About Charles River

Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.


With over 14,000 employees within 80 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2018, revenue increased by 22% to $2.27 billion from $1.86 billion in 2017.


At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2018.


Charles River Laboratories is an Equal Opportunity Employer - M/F/Disabled/Vet. If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.



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