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Research Associate I, Mass Spectrometry

Req ID #:  40657
Location: 

Shrewsbury, MA, US, 01545

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Job Summary

We are seeking an experienced Research Associate I – Mass Spectrometry for our Biologics group currently located in Woburn, MA but relocating to Shrewsbury, MA in Q2/Q3 of 2019.

 

In this position, the Research Associate I will assist their supervisor and other scientific staff by working independently on mass spectrometry testing, data interpretation, and reporting following documented test methods and procedures. Perform cGMP Method Qualification and ICH Validation work as assigned. 

 

Specific areas of testing support may include the following areas:

  • Various methodologies developed for QTOF, Orbitrap, and Triple Quadrupole including:
  • Peptide Mapping LC-UV-MS/(MS)
  • Intact Molecular Weight Analyses LC-UV-MS
  • N- and O-Linked Glycosylation Profiling
  • Glycopeptide Mapping via LC-MS/MS
  • Sample Preparation such as SDS PAGE, SPE, HPLC Peak Collection
  • Use of Agilent and Thermo UPLC and MS Platforms

 

Perform laboratory activities necessary for mass spectrometry testing including but not limited to reagent preparation, laboratory maintenance/monitoring, routine testing of client samples, and the generation of routine GMP and R&D grade reports  For both cGMP and R&D grade routine testing, generate mass spectrometry data and technical report(s) on-time with respect to internal and client deadlines.  Maintain a weekly schedule to ensure all timelines are met.  Execute protocols for the cGMP qualification and/or ICH Validation of HPLC and mass spectrometry assays.  Maintain/update sample-tracking and chemical inventory databases for the laboratory.  Make detailed observations and maintain clear, accurate and timely documentation of all laboratory work.  Practice and ensure compliance with all pertinent regulatory standards regarding environs, equipment and testing services.  Maintain a safe working environment. Actively participate in laboratory maintenance.  Compose high quality written reports such as technical reports, deviation reports and Change Control documentation with guidance. Create, review and edit SOPs, protocols and other data forms and testing documentation.

 

The following are minimum requirements related to the Research Associate I – Mass Spectrometry position.

  • Bachelor’s degree (B.A./B.S.) or equivalent in biology or related discipline.
  • Minimum 3 years related industry experience in a mass spectrometry laboratory in the Pharmaceutical, Biotech or contract research laboratory (CRO) environment. 
  • An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above.
  • Computer proficiency in MS Word, Excel, Outlook, instrumentation and analysis software. Excellent verbal, written communication and organizational skills. Possess excellent interpersonal skills to maintain communication across functional groups. Able to communicate effectively in a small group or one on one setting. 
  • While performing the duties of this job, regularly required to walk, sit, stoop, kneel and stand; use hands to finger, handle, or feel objects, tools, or controls; reach with hands and arms; use a microscope and other analytical equipment; talk or hear; and type at a computer. 
  • The employee must occasionally lift and/or move up move up to 25 pounds.
  • Specific vision abilities required by this job include close vision, distance vision, depth perception, and the ability to adjust focus.
  • May have exposure to potential chemical, electrical, biological and waste-handling hazard.

About Biologics Testing Solutions

With more than 50 years of experience and proven regulatory expertise, the Charles River Biologics group can address challenging projects for biotechnology and pharmaceutical companies worldwide. Offering a variety of services such as contamination and impurity testing, protein characterization, bioassays, viral clearance studies and stability and lot release programs, we support clients throughout the biologic development cycle, from the establishment and characterization of cell banks through preclinical and clinical studies to marketed products. Whether clients need stand-alone services, a unique package of testing, or insourced support, our Biologics group can create a custom solution to suit their needs.  Each year more than 20,000 biologic testing reports are sent each and over 200 licenses products are supported by our biologics testing solutions team.

 

About Charles River

Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

 

With over 13,000 employees within 80 facilities in 23 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges.  Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world.

 

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of 80% of the drugs approved by the FDA in 2017.

 

For more information, please visit www.criver.com.

 

Equal Employment Opportunity

Charles River Laboratories, Inc. is an Equal Opportunity Employer M/F/Disabled/Vet

 


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