Director, In Vivo Operations

Req ID #:  220808

Durham, NC, US, 27709

For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Job Summary

We are seeking a Director, In Vivo Operations for our Discovery site located Durham, NC.
Oversee the In Vivo Operations Department, encompassing In Vivo, Necropsy, Formulations, and Animal Care Departments, with responsibility for monitoring the overall conduct and quality of activities performed in support of non-clinical research studies.  These responsibilities include submitting and reviewing operational SOP’s and adherence, recruitment of staff, working collaboratively with other departments, and continuous improvement of processes and structure to meet business objectives.

The following are responsibilities related to the Director, In Vivo Operations:


  • Provide vision and organizational structure to the In Vivo Department to align with business needs and site objectives.  Accomplish this through a mindset of continuous improvement and assessment against business objectives.
  • Align in vivo operations to the needs of the business through performance and structural optimization. 
  • Drive operational efficiencies through operational evaluation and improvement to include changes in process and introduction of new digital tools.
  • Anticipate business operational problems and initiate discussions for improvements.
  • Work directly across departments to address communication, quality, or technical issues.
  • Oversee interactions between in vivo and in vitro technical operations, training, resource management, formulations, and client facing staff to ensure smooth conduct of in vivo studies.
  • Work with facility management and Attending Veterinarian to ensure biosecurity and environmental monitoring is conducted and address potential issues.
  • Represent in vivo activities in client related communications, presentations, and meetings.
  • Ensure a positive employee relations position is maintained and that effective communication is maintained to inform employees of business development, project management and marketing plans and progress.
  • Coordinate and partner with Client Services to ensure the needs of the customer are satisfied and appropriate from lead inquiry to project completion including transparent communication processes with the rest of CRL. 
  • Responsible for personnel management activities such as: scheduling, personnel actions (hiring, promotions, transfers, etc.), training and development, providing regular direction and feedback on performance, disciplinary actions and preparing and delivering annual performance and salary reviews.
  • Develop short- and long-range operating objectives, organizational structure, staffing requirements and succession plans.
  • Develop and recommend departmental budget expenditures.
  • Develop and oversee the implementation of departmental training programs related to business operations, including orientation.
  • Support the policy of equal employment opportunity through affirmative action in personnel actions.
  • Ensure adherence to pertinent regulatory requirements and to departmental policies, practices and procedures [SOPs, safety procedures and biosafety protocols].

Job Qualifications


The following are minimum qualifications related to the Director, In Vivo Operations position:


Education: Bachelor’s degree (B.A./B.S.) or equivalent in Animal Science or related discipline.
Experience:  Minimum of 8 years related technical experience in a non-clinical research laboratory with experience supervising in a laboratory environment. 5 years management/supervisory experience.
An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above.
Certification/Licensure:  LATG preferred, applicable certifications & licensure preferred.
Other:  Strong leadership skills.  Excellent organizational skills and the ability to prioritize and meet deadlines.  Excellent communication (both written and verbal).  Effective facilitation and negotiation skills.   Ability to interact appropriately with all levels of employees.

The pay range for this position is $138,000 to $155,000. Please note that salaries vary within the range based on factors including, but not limited to, experience, skills, education, certifications, and location.


Lead - We lead when we advocate our purpose and model our values, when we deliver innovation, when we embrace change, and when we appreciate and celebrate the great work of others.
Care - We show we care when we respect each other, our animals and the communities where we work and live, when we create a positive healthy workplace, when we are mindful of our compliance standards, and when we choose to do the right thing.
Collaborate -We collaborate when we partner with each other and promote teamwork, when we communicate clearly and effectively across the hall or around the globe, and when we welcome all forms of diversity and encourage inclusiveness.
Own - We act like owners when we hold ourselves accountable for our actions, when we respond to internal and external client needs with speed and accuracy, when we set and achieve meaningful goals, and when we strive towards continuous improvement.

About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 320 patents and 74 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.


About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.


With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. 


At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of 86% of the drugs approved by the FDA in 2021.


Equal Employment Opportunity
Charles River Laboratories is an Equal Opportunity Employer - all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, or national origin, veteran or disability status.


If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to [email protected]. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.


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Nearest Major Market: Durham
Nearest Secondary Market: Raleigh

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