Research Support Specialist 4 (TB3)

Req ID #:  100891

Bethesda, MD, US, 20892

At Charles River, we are passionate about improving the quality of people’s lives. When you join our global family, you will help create healthier lives for millions of patients and their families. 


Charles River employees are innovative thinkers, who are dedicated to continuous learning and improvement. We will empower you with the resources you need to grow and develop in your career. 


As a Charles River employee, you will be part of an industry-leading, customer-focused company at the forefront of drug development. Your skills will play a key role in bringing life-saving therapies to market faster through simpler, quicker, and more digitalized processes. Whether you are in lab operations, finance, IT, sales, or another area, when you work at Charles River, you will be the difference every day for patients across the globe.


IMPORTANT:   In order to be considered for this position, a resume/CV must be uploaded and submitted during the application process.  Please make sure work history and education are added correctly.   


Job Summary

We are seeking a Research Support Specialist 4 for our Insourcing Solutions site located in Bethesda, MD.


The following are responsibilities related to the Research Support Specialist 4 position:

•Perform genome modification of mice via CRISPR/cas9 microinjections in embryos to create gene Knock out and gene knock in animals, production of transgenic mice via pronuclear injection.
•Perform injections of gene targeted embryonic stem (ES) cells into blastocysts to create chimeric mice.
•Assist with the cryopreservation of mouse germplasm, including freezing and storage of sperm.
•Rederive of lines from frozen embryos and sperm via in vitro fertilization, maintaining of animal colonies to augment the existing cryopreservation and rederivation program.
•Provide rodent genotyping assistance by collecting samples from gene modified animals. 
•Prepare tissue, and germplasm samples for transport and storage utilizing liquid nitrogen.
•Maintain integrity of the embryo rederivation efforts, including detailed accurate record keeping and routine breeder observations.
•Ability to work flexible hours and with other team members to ensure research needs and experiments are carried out to comply with appropriate timelines.

Job Qualifications

The following are minimum qualifications related to the Research Support Specialist 4 position:

•PhD degree with 3 to 5 years of lab experience in molecular biology, genetics, biochemistry or related fields
•Must have experience in applying genetics knowledge to the laboratory animal field relating to genetically engineered mice (GEM) including embryo manipulations, gene targeting in embryonic stem (ES) cells and development of gene constructs for production of GEM.



IMPORTANT: A resume is required to be considered for this position. If you have not uploaded your resume in your candidate profile, please return to upload field and attach your resume/CV. 

About Corporate Functions
The Corporate Functions provide operational support across Charles River in areas such as Human Resources, Finance, IT, Legal, Sales, Quality Assurance, Marketing, and Corporate Development. They partner with their colleagues across the company to develop and drive strategies and to set global standards. The functions are essential to providing a bridge between strategic vision and operational readiness, to ensure ongoing functional innovation and capability improvement.  

About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increased to $2.62 billion.

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2019.

Equal Employment Opportunity
Charles River Laboratories is an Equal Opportunity Employer - M/F/Disabled/Vet.

If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.

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