Research Scientist I / Research Scientist II Method Development - Bioanalytical Chemistry

Req ID #:  222288

Ashland, OH, US, 44805

For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Job Summary

We are seeking an experienced Research Scientist I and/or Research Scientist II for our Bioanalytical Chemistry team located in Ashland, OH.

Serve as a scientist in the conduct of assigned nonclinical or clinical LCMS/GCMS research studies of moderate to high complexity, to include study management, interpretation and reporting of study data, and assuring the regulatory compliance of these projects. Candidates with experience in large molecules and oligonucleotide analysis are highly encouraged to apply.


ESSENTIAL DUTIES AND RESPONSIBILITIES:  (The fundamental Competencies/Skills & Responsibilities of the role (products and services provided/results accomplished) include, but are not limited to, those listed:  

  • Research, design and execute LCMS/GCMS-based experiments for the characterization of biotherapeutics.

  • Efficiently perform and document all procedures, materials, and results in compliance with applicable regulatory standards as applicable (protocols, methods, SOPs, etc.).

  • Independently execute the completion of laboratory investigations, assay troubleshooting, quality observations, and problem solving of technical and/or regulatory issues.

  • Independently develop and test quantitative/qualitative methods/procedures with increased complexity/scope in one operational area. 

  • Actively communicate and collaborate across operational areas in order to adhere to timelines and produce quality data.

  • Develop and maintain critical thinking, troubleshooting, and time management skills aligned with needs of operational areas.

  • Demonstrate effective communication skills through informal discussions with peers, supervisor, and team. 

  • Able to recognize method and/or data issues and communicate them to management to minimize study impact independently.

  • Independently prepare summary of method development data. 

  • Independently execute review and approval of data for final scientific/technical decisions.

  • Responsible for reviewing the analytical procedures protocols independently. 

  • Independently function as the scientific expert with internal and external stakeholders 

  • Independently ensure scientific integrity of studies. 

  • Provide support to staff members as required by operational areas, as needed. 

  • Lead internal process improvements and training staff. 

  • Attend scientific meetings, conferences, and training courses to enhance job and professional skills.

  • Perform all other related duties as assigned.


The pay range for the RS1 position is 85-90K and the RS2 position is 100-115K. Please note that salaries vary within the range based on factors including, but not limited to, experience, skills, education, certifications, and location.

Job Qualifications

(Knowledge, Experience, Skills and Abilities required to accomplish the essential functions) include but are not limited to: 


  • Education and experience: Bachelor's degree (B.A./B.S.) in a related scientific discipline with 8 to 11 years of related lab experience, Master's degree (M.A./M.S.) with 5 to 7 years of relevant experience or Ph.D./D.V.M. with at least 3 years of related experience. PhD is strongly recommended.

  • Certification/Licensure: None.

  • Other:  Understanding of operating LCMS/GMS instruments and other typical small laboratory equipment, ability to manage multiple projects and prioritize work to meet deadlines, capable of data interpretation of biotherapeutics (metabolites, peptides and proteins, oligonucleotides) using analytical software (i.e. Analyst and Chromeleon), ability to learn Testing Facility SOPs and the Good Laboratory Practices (GLPs), as appropriate. Demonstrate leadership skills as they pertain to intra- and interdepartmental initiatives, Sponsor interactions, and business development. Effective written and verbal communication skills. Proficiency in the use of standard software including Microsoft® Excel, Word, PowerPoint, etc. and with standard laboratory calculations.



  • Must be able to lift, move, manipulate and/or hold heavy objects up to and including 10 pounds; this includes work materials, equipment, and/or supplies.

  • Must be able to perform procedures, standing or sitting, for long periods of time, using appropriate instruments, reaching with hands and arms, working in narrow spaces, and wearing safety equipment (PPE) according to OSHA regulations and company standards.

  • Must be able to frequently hold and manipulate work materials while utilizing fine motor skills.

  • Must be able to regularly provide information to and receive information from/through various technologies, media, sources, and contacts. Must be able to accurately exchange information in these situations.

  • Regularly operates a computer and other office productivity machinery, 

  • Move about inside the work area to access file cabinets, office machinery, etc.

  • Specific vision abilities required by this job include close vision, color vision, depth perception, and the ability to adjust focus.



  • General office and lab working conditions, the noise level in the work environment is usually quiet.

  • While performing the duties of this job the employee is regularly required to wear protective clothing (i.e., goggles, face shield, cap, gloves, scrubs, shoe covers), work near toxic or caustic chemicals, and work with biohazards.

  • The noise level in the work environment ranges from low to moderate depending upon the task being performed.

About Safety Assessment
Charles River is committed to helping our partners expedite their preclinical drug development with exceptional safety assessment services, state-of-the-art facilities and expert regulatory guidance. From individual specialty toxicology and IND enabling studies to tailored packages and total laboratory support, our deeply experienced team can design and execute programs that anticipate challenges and avoid roadblocks for a smooth, efficient journey to market.  Each year approximately 300 investigational new drug (IND) programs are conducted in our Safety Assessment facilities.


About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.


With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world.


At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of 86% of the drugs approved by the FDA in 2021.


Equal Employment Opportunity

Charles River Laboratories is an Equal Opportunity Employer - all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.


If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to [email protected]. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.


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Nearest Major Market: Cleveland
Nearest Secondary Market: Mansfield

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