Research Scientist 2 (Safety Pharmacology)

Req ID #:  53175

Ashland, OH, US, 44805

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Job Summary

We are seeking a Research Scientist 2 for our Safety Assessment Group site located in Ashland, OH.


The ideal candidate will be a subject matter expert in the field of cardiovascular physiology (cardiac electrophysiology experience a plus) whose experience has been gained through a combination of academic and laboratory research settings.  In addition, the candidate will have experience with ex-vivo preparations (e.g., isolated heart preparations and/or isometric tissue bath assays), cardiovascular biomarker collection and analysis, cell and/or tissue electrophysiology, and proficiency with data acquisition/analysis software (e.g., EMKA and DSI) is preferred.  This position will require a candidate with strong leadership skills and demonstrated publication history in the field of cardiovascular physiology (Safety Pharmacology) preferred.



  • Function independently as a study director in the direction and execution of assigned studies in compliance with GLP regulations as they apply to the conduct of nonclinical research.
  • Participate in and coordinate all phases of the study planning process with appropriate departments.
  • Generate high-quality protocols, amendments, and reports appropriate for assigned studies.
  • Review, interpret, integrate, and present data on assigned studies with minimal assistance.
  • Function independently as contact for the planning and execution of sponsor interaction related to assigned studies, including proposal management and study scheduling, conduct and reporting.
  • Assist in the oversight of the laboratory and mentor technical staff in areas such as protocol interpretation, method development and refinement, study-related problem resolution, and technique validation.
  • Review reports for peers as needed.
  • Provide technical and scientific guidance to the research staff.
  • Ability to work with/lead multiple teams and/or working groups within the Safety Pharmacology discipline.
  • Attend scientific meetings, conferences and training courses to enhance job and professional skills.
  • May supervise research and/or scientific staff, as appropriate for scope of responsibilities.
  • Perform testing facility management duties for the site as delegated by senior management.



  • Education: Bachelor's degree (B.S./B.A.) or equivalent in a scientific related discipline. Related Master's degree (M.S./M.A.) or Ph.D./D.V.M. preferred.
  • Experience:  Minimum of 8 to 9 years related experience in the contract research, academic, or pharmaceutical industry. Safety Pharmacology study director experience preferred.
  • Electrophysiology experience preferred.
  • Demonstrated experience/ability with ex-vivo (Langendorff) and tissue bath (aortic ring) assays preferred. 

About Safety Assessment
Charles River is committed to helping our partners expedite their preclinical drug development with exceptional safety assessment services, state-of-the-art facilities and expert regulatory guidance. From individual specialty toxicology and IND enabling studies to tailored packages and total laboratory support, our deeply experienced team can design and execute programs that anticipate challenges and avoid roadblocks for a smooth, efficient journey to market.  Each year approximately 120 investigational new drug (IND) programs are conducted in our Safety Assessment facilities.


About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.


With over 14,000 employees within 80 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2018, revenue increased by 22% to $2.27 billion from $1.86 billion in 2017.

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2018.


Equal Employment Opportunity 


Charles River Laboratories is an Equal Opportunity Employer - M/F/Disabled/Vet


Nearest Major Market: Cleveland
Nearest Secondary Market: Mansfield

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