Sr. Research Assistant

Req ID #:  134173
Location: 

Wilmington, MA, US, 01887


For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

 

IMPORTANT:   In order to be considered for this position, a resume/CV must be uploaded and submitted during the application process.  Please make sure work history and education are added correctly.   

Job Summary

We are seeking a Sr. Research Assistant to work in our GEMS Embryology department at our Wilmington, MA location. The Sr. Research Assistant will use current state-of-the-art techniques to generate novel rodent disease and research models for clients and collaborators, design and execution of research projects focused on application of assisted reproductive technology (ART) in rodents.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

  • Perform model creation in mice and rats using microinjection of embryonic stem cells (ESCs) into 8-cell and blastocyst stage embryos as well as direct injection of CRISPR reagents at pronuclear stage. 
  • Perform model creation in mice and rats using electroporation base approaches including direct electroporation of embryos as well as GONAD and i-GONAD.
  • Coordinate receipt of modified ESCs and CRISPR reagents from collaborators, assure their proper storage, and maintain an accurate inventory record.
  • As required, thaw and maintain ESC cultures.
  • Perform other technical procedures related to rodent model creation including but not limited to: embryo transfer, collection of embryos from oviduct and uterine tissue of naturally mated rodents, collection of mature sperm and oocytes from rodent reproductive tracts to use in in vitro fertilization (IVF), ex vivo embryo culture, cryopreservation of sperm and embryos, assessment of rates of chimerism.   
  • Stay informed in the current state-of-the-art techniques related to ART and model creation in rodents. 
  • Participate in design and execution of research projects focused on expanding the application of ART and model creation in rodents and on the improvement of laboratory processes.
  • Present results at regular internal laboratory meetings, at scientific conferences, and through publication in peer reviewed journals. 
  • Serve as a Subject Matter Expert (SME) on topics related to model creation in rodents.
  • Ensure proper record-keeping.
  • As necessary assist the embryology production lab.
  • Handle rodents, perform necessary sample collection, and occasionally participate in husbandry duties. 
  • As necessary work in an isolator following all biosecurity procedures necessary to maintain integrity and animal health status. 
  • Mentor and train new personnel. 
  • Unnderstand and comply with all Standard Operating Procedures (SOPs).
  • Follow all local, state, and federal laws governing the use of research animals.
  • Work under deadlines with general guidance.
  • Work on weekends and holidays as required.
  • Perform all other related duties as assigned. 

MINIMUM QUALIFICATIONS:

  • Associate degree (A.A. /A.S.) or higher degree equivalent in Biological Science, Lab Animal Science, or related discipline.  
  • 2 years related experience and/or training.
    • An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above.
  • Proficient in computers (i.e.:  MS Office Suite and knowledge of databases).
  • Must possess a high level of initiative and ability to work with little supervision.
  • Broad knowledge of biology laboratory practices.
  • Knowledge and experience in use and creation of rodent disease models.

 

PREFERRED QUALIFICATIONS:

  • Master's degree or PhD.
  • Extensive experience working with rodents.

 

 


IMPORTANT: A resume is required to be considered for this position. If you have not uploaded your resume in your candidate profile, please return to upload field and attach your resume/CV. 
 


About Research Models & Services 
Fundamental to basic research and discovery is the use of in vivo models to help identify disease targets and determine potential biological pathways that regulate the condition.  As the world’s leader in the production and distribution of the highest quality research animal, with 1 out of 2 animal models produced for preclinical research globally, we understand the importance of this step. With seven decades of experience, our expertise is unmatched, allowing us to provide you with the perfect model, including disease-specific and preconditioned options, for basic research and beyond. 
 

About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increased to $2.62 billion.

 
At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2019.
 

Equal Employment Opportunity
Charles River Laboratories is an Equal Opportunity Employer - M/F/Disabled/Vet.

If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to crrecruitment_US@crl.com. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.

For more information, please visit www.criver.com.


Nearest Major Market: Boston

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