Embryology Scientist I

Req ID #:  180416
Location: 

Wilmington, MA, US, 01887

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.


IMPORTANT:   In order to be considered for this position, a resume/CV must be uploaded and submitted during the application process.  Please make sure work history and education are added correctly.

Job Summary

The GEMS Embryology department is looking for an Embryology Scientist 1 for the Wilmington, MA location. The roles of the position include use of current state of the art techniques to generate novel rodent disease and research models for clients and collaborators, rederivation and cryopreservation of client lines, design and execution of research projects focused on improving the application of assisted reproductive technology (ART) in rodents, communication of results internally to department and management and externally to clients and broader scientific community. 


ESSENTIAL DUTIES AND RESPONSIBILITIES:

  • Perform model creation in mice and rats using microinjection of embryonic stem cells (ESCs) into 8-cell and blastocyst stage embryos as well as direct injection of CRISPR reagents at pronuclear stage. 
  • Perform model creation in mice and rats using electroporation base approaches including direct electroporation of embryos as well as GONAD and i-GONAD.
  • Coordinate receipt of modified ESCs and CRISPR reagents from collaborators, assure their proper storage, and maintain an accurate inventory record.
  • As required, thaw and maintain ESC cultures.
  • Perform other technical procedures related to rodent model creation including but not limited to: embryo transfer, collection of embryos from oviduct and uterine tissue of naturally mated rodents, collection of mature sperm and oocytes from rodent reproductive tracts to use in in vitro fertilization (IVF), ex vivo embryo culture, cryopreservation of sperm and embryos, assessment of rates of chimerism.   
  • Stay informed in the current state of the art techniques related to ART and model creation in rodents. 
  • Participate in design and execution of research projects focused on expanding the application of ART and model creation in rodents and on the improvement of laboratory processes.
  • Work under general supervision. 
  • Present results at regular internal laboratory meetings, and occasionally at scientific conferences, and through publication in peer reviewed journals. 
  • Ensure proper record-keeping.
  • As necessary assist the embryology production lab.
  • Handle rodents, perform necessary sample collection, and occasionally participate in husbandry duties. 
  • As necessary work in an isolator following all biosecurity procedures necessary to maintain integrity and animal health status. 
  • Mentor and train new personnel. 
  • Understand and comply with all Standard Operating Procedures (SOPs).
  • Follow all local, state, and federal laws governing the use of research animals.
  • Work under deadlines with general guidance.
  • Work on weekends and holidays as required.
  • Perform all other related duties as assigned. 

MINIMUM QUALIFICATIONS:

  • Bachelor’s degree (B.S.) in Biological Science, Lab Animal Science, or related discipline.  
  • 4 years of relevant experience and/or training in rodent model creation and use of ART in rodents.
    •  An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above.
  • Proficient in computers (i.e.:  MS Office Suite and knowledge of databases).
  • Must possess a high level of initiative and ability to work with little supervision.
  • Broad knowledge of biology laboratory practices.
  • Knowledge and experience in use and creation of rodent disease models.

 

PREFERRED QUALIFICATIONS:

  • Master's degree or PhD.
  • Extensive experience working with rodents.
     

IMPORTANT: A resume is required to be considered for this position. If you have not uploaded your resume in your candidate profile, please return to upload field and attach your resume/CV. 


Vaccine Mandate
Charles River is a U.S. Federal Contractor.  As a result, we must follow the Presidential Executive Order to mandate vaccinations, and ensure our employees are fully vaccinated against COVID-19.  Our main priority is the wellbeing, health, and safety of our people. We require proof of vaccination from all employees. 


Anyone with requests for disability-related and/or religious exemptions should contact Talent Acquisition (crrecruitment_US@crl.com) so that information can be provided about the accommodation process at Charles River.

 

About Research Models & Services 
Fundamental to basic research and discovery is the use of in vivo models to help identify disease targets and determine potential biological pathways that regulate the condition.  As the world’s leader in the production and distribution of the highest quality research animal, with 1 out of 2 animal models produced for preclinical research globally, we understand the importance of this step. With seven decades of experience, our expertise is unmatched, allowing us to provide you with the perfect model, including disease-specific and preconditioned options, for basic research and beyond. 


About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.


With over 18,000 employees within 100 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. 


At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of >80% of the drugs approved by the FDA for the past 3 years.


Equal Employment Opportunity
Charles River Laboratories is an Equal Opportunity Employer - all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.


 
If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to crrecruitment_US@crl.com. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.

 

For more information, please visit www.criver.com.


Nearest Major Market: Boston

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