Senior Scientist, Cell Engineering

Req ID #:  169931
Location: 

South San Francisco, CA, US, 94080

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Job Summary

.At Distributed Bio, now a part of Charles River Laboratories, our mission is to define a new paradigm in revolutionary bioengineered medicines for the biotechnology industry. In monoclonal therapeutics, our integration of computational immunology, bioengineering and robotics has enabled us to create a pipeline of molecules with unprecedented biophysical properties, while also supporting our partners with developable antibodies against any drug target of interest.
Our ability to discover antibodies against challenging pMHC, pathogen toxins, GPCR and Ion Channel targets, as well as a novel high-throughput discovery of CAR-T, has resulted in the growth of our antibody discovery business.
 
Overview:
We are seeking a candidate with knowledge in the fields of Immunology, molecular Immunology and antibody discovery. This position will lead a team driving the experimental design and execution of research in antibody discovery, cell biology, immunology and assay development.  Major responsibilities will include working with internal teams and external partners to define and interrogate relevant biology and antibody mechanism of action, to enable lead candidate selection with the goal of developing novel therapeutic approaches. 
 
Responsibilities:

  • Work closely with internal and external research partners on the design and execution of antibody discovery campaigns
  • Supervise and mentor a team of 2-4 direct reports committed to delivering IND-enabling packages in support of these targets
  • Oversee the generation and analysis of data from the Cell Biology team, and from across the organization
  • Analyze data generated by the entire team to ensure consistency and quality
  • Document data in lab notebook and ensure periodic peer review.
  • Present data for review, group discussions, team meetings, to research partners and appropriate international conferences (ASGCT, AACR and others)
  • Multi-task effectively and prioritize multiple projects.
  • Advocate for technology development within the site:
  • Work with other team leaders to develop and advance next-generation technologies to drive antibody discovery in the next 2-5 years
  • Partner with key leaders at other CRL sites to enable successful project execution
  • Contribute to the design and implementation of the CRL’s South San Francisco Bio-hub
  • Keep current with latest scientific advances in the field, as a though leader and spokesperson for relevant research
  • Present data for review in group discussions and team meetings, to internal and external stakeholders, and at appropriate international conferences (e.g., ASGCT, AACR, PEGS):
  • Cell culture expertise including maintaining mammalian cell lines, isolating immune cells from PBMCs, cell differentiation in culture, and generating cell lines using lentiviral transduction and cell sorting as needed.
  • Proficiency in multicolor flow cytometry techniques, including the proper usage of flow cytometry analyzers and sorters
  • Proficiency with FlowJo and Prism for the analysis and presentation of data
  • Familiarity with analytical methods including ELISA, multiplex cytokine assays etc.
  • Familiarity with cell-based functional assays, including: proliferation and activation assays of primary immune cells and cell lines, and the use of reporter cell assays based on luminescence, ATP assay, calcium flux etc.
  • Supervision of molecular biology techniques such as: RNA and DNA isolation, primer design, cloning, PCR and Real time PCR.

Job Qualifications

Qualifications:

 

  • Masters or PhD in Immunology, antibody discovery, or related fields, with a minimum of 5 years of laboratory experience in industry strongly preferred
  • Strong skills in mammalian cell culture and flow cytometry techniques are essential
  • Demonstrated ability to lead a team and supervise experienced scientists
  • Ability to design and deliver novel solutions to challenging problems
  • Keen eye for detail and for keeping multiple projects moving along to timelines
  • Highly motivated with a strong willingness to learn and grow
  • Must be able to work productively in a fast-paced, collaborative team environment
  • Excellent communication skills are essential

Vaccine Mandate
Charles River is a U.S. Federal Contractor.  As a result, we must follow the Presidential Executive Order to mandate vaccinations, and ensure our employees are fully vaccinated against COVID-19.  Our main priority is the wellbeing, health, and safety of our people. We require proof of vaccination from all employees. 


Anyone with requests for disability-related and/or religious exemptions should contact Talent Acquisition (crrecruitment_US@crl.com) so that information can be provided about the accommodation process at Charles River.

 

About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 320 patents and 74 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.


About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.


With over 18,000 employees within 100 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. 


At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of >80% of the drugs approved by the FDA for the past 3 years.


Equal Employment Opportunity
Charles River Laboratories is an Equal Opportunity Employer - all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.


 
If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to crrecruitment_US@crl.com. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.

 

For more information, please visit www.criver.com.


Nearest Major Market: San Francisco
Nearest Secondary Market: Oakland

Job Segment: Cell Biology, Research Scientist, Molecular Biology, Pharmaceutical, Biology, Science