Scientist I - Mass Spectrometry

Req ID #:  45630

Shrewsbury, MA, US, 01545

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

We are seeking an experienced Scientist I – Mass Spectrometry for our Biologics group located in Shrewsbury, MA.


In this position, the Scientist I will assist in the development of methods related to the testing and characterization of biotherapeutics using mass spectrometry.  Under minimal supervision, may be responsible for method development, client interaction, interpretation and reporting of data, and regulatory compliance of assigned research projects. 

Also, will perform routine testing techniques such as the following with a high degree of reliability, efficiency and accuracy:

  • Various methodologies developed for QTOF, Triple Quadrupole, and Orbitrap mass spectrometry such as:
  • Peptide Mapping LC-UV-MS/(MS)
  • Intact Molecular Weight Analyses LC-UV/MS
  • Sample Preparation such as SDS PAGE, SPE, HPLC Peak Collection
  • Glycosylation Site Mapping via LC-MS/MS
  • N- and O- Linked Glycosylation Profiling
  • Proteomic sample preparation and data processing
  • Use of Agilent and Thermo MS Platforms


The following are minimum requirements related to the Scientist I – Mass Spectrometry position.

  • Bachelor’s degree (B.A./B.S.), M.S., or equivalent in Chemistry/Biotechnology, Ph.D. is preferred.
  • Minimum of three years’ experience within a contract research, academic or pharmaceutical industry, including experience in the core competencies of characterization and analysis of biotherapeutics.
  • An equivalent combination of education and experience with contract research or the pharmaceutical industry may be accepted as a satisfactory substitute for the specific education and experience listed above.
  • Ability to work on problems of moderate scope where analysis of situation or data requires a review of identifiable factors.  Exercises judgment within defined procedures and practices to determine appropriate action.  Effective written and verbal communication skills with the ability to handle multiple projects, prioritize work and meet deadlines within a cGMP environment.  Capable of data interpretation of basic characterization and analysis of biotherapeutics (glycoproteins and peptides) using mass spectrometry.  Capable of anticipating and recognizing potential problems.  Must be able to follow written and verbal instructions and possess good interpersonal skills that are conducive to effective communication.

About Biologics Testing Solutions

With more than 50 years of experience and proven regulatory expertise, the Charles River Biologics group can address challenging projects for biotechnology and pharmaceutical companies worldwide. Offering a variety of services such as contamination and impurity testing, protein characterization, bioassays, viral clearance studies and stability and lot release programs, we support clients throughout the biologic development cycle, from the establishment and characterization of cell banks through preclinical and clinical studies to marketed products. Whether clients need stand-alone services, a unique package of testing, or insourced support, our Biologics group can create a custom solution to suit their needs.  Each year more than 20,000 biologic testing reports are sent each and over 200 licenses products are supported by our biologics testing solutions team.


About Charles River

Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.


With over 14,000 employees within 80 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2018, revenue increased by 22% to $2.27 billion from $1.86 billion in 2017.


At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2018.


Equal Employment Opportunity 


Charles River Laboratories is an Equal Opportunity Employer - M/F/Disabled/Vet




Nearest Major Market: Worcester

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