Laboratory Technician, Biophysical - $750 sign-on bonus

Req ID #:  144171

Shrewsbury, MA, US, 01545

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Basic Summary

Under direct supervision, perform biophysical methods as specified in standard in-house SOPs, Client Test Methods, and other written procedures.  



  • Independently perform laboratory activities including but not limited to: 
    • reagent preparation,
    • laboratory cleaning,
    • maintenance/monitoring of laboratory equipment,
    • routine testing of client samples,
    • generation of routine cGMP and R&D reports. 
  • Develop understanding of processes and procedures used within the biophysical characterization department with a specific focus on Routine Testing.
  • This includes:
    • understanding of sample type,
    • purpose of test selection,
    • necessary supplies and documentation expectations
    • developing the ability to troubleshoot and problem solve with scientific guidance.
  • Become proficient in performing a minimum of 1 of the below listed BioPhysical department routine testing methods with a high degree of reliability, efficiency and accuracy:
    • Analytical Ultracentrifugation (AUC)
    • Size Exclusion HPLC-MALLS (SEC-MALLS)
    • Differential Scanning Calorimetry (DSC)
    • Intrinsic Tryptophan Fluorescence (ITF)
    • Fourier Transform Infrared (FTIR)
    • Dynamic Light Scattering (DLS)
    • Protein Binding via SPR-Biacore
    • Circular Dichroism (CD)
    • Develop and maintain excellent laboratory techniques including: 
    • pipetting 
    • weighing material on an analytical balance
    • reagent preparation 
  • Update sample-tracking databases and maintain chemical/consumables inventory for the laboratory.
  • Analyze data and report results of experiments and procedures.
  • Competently perform peer review of data as needed.
  • For cGMP and R&D grade routine testing, generate biophysical data and technical report (s) on-time with respect to internal and client deadlines.  
  • Maintain a weekly schedule to ensure all timelines are met.
  • Maintain a safe working environment by adhering to company policies and procedures.  Actively participate in laboratory maintenance.
  • Comply with all pertinent regulatory standards regarding environs, equipment and testing services.
  • Make detailed observations and maintain clear, detailed, accurate and timely documentation of all laboratory work. 
  • Compose high quality documentation including deviation reports and change control documentation under guidance. 
  • Follow all SOP’s, CTMs and cGMP documents as they relate to specific tasks.
  • Assist in the training of junior staff.
  • Maintain up to date training records on all procedures and protocols applicable to work duties.
  • Ability to work in a structured and regulated environment.
  • Work productively in group settings as well as individually. 
  • Perform all other related duties as assigned.


  • Bachelor’s degree (B.S.) or equivalent in biochemistry, chemistry, or related discipline.
  • 0 to 2 years related industry experience in an analytical science area in the Pharmaceutical, Biotech or contract (CRO) laboratory environment.  
  • An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above.
  • Knowledge of cGMPs or regulatory affairs pertaining to the pharmaceutical and biological industries is preferred.  
  • Knowledge of basic protein /peptide biophysical techniques and ability to operate typical laboratory equipment, specifically HPLC, spectrophotometer, dialysis/buffer exchange via SPE, and other laboratory equipment a plus.  
  • Strong organizational and prioritization skills required.
  • Attention to detail and accuracy a must.  
  • Ability to collaborate effectively within a group environment.
  • Able to communicate effectively (verbal and written) in a small group or one on one setting.
  • Basic Microsoft Office skills are required.
  • Ability to understand and use internal software programs such as LIMS required. 


  • Must be able to remain in a stationary position 50% of the time while performing laboratory tasks.
  • Regularly observes, inspects, and interprets laboratory experiments, requiring close vision and the ability to adjust focus and detect and differentiate colors. 
  • Frequently and accurately operate laboratory pipettes.
  • Regularly lift and/or move up to 10 pounds and may occasionally lift and/or move up to 50 pounds. 


  • General laboratory working conditions.
  • Regularly wears protective clothing (cap, gloves, scrubs, lab coat, safety glasses).
  • Regularly works with or near toxic or caustic chemicals.
  • May be exposed to fumes or airborne particles.
  • Regularly works at a chemical fume hood.
  • Occasionally works near moving mechanical parts.
  • May work with biohazards.
  • Occasionally may be exposed to unpleasant odors.
  • The employee may work with sharp objects (i.e. needles, glass pipettes, pipet tips).
  • This position may require overtime, weekend, holiday, and/or after hours shift coverage, as needed. 

Vaccine Mandate
Charles River is a U.S. Federal Contractor.  As a result, we must follow the Presidential Executive Order to mandate vaccinations, and ensure our employees are fully vaccinated against COVID-19 by December 8, 2021.  Our main priority is the wellbeing, health, and safety of our people. We will be requiring proof of vaccination from all employees. 

Anyone with requests for disability-related and/or religious exemptions should contact Talent Acquisition ( so that information can be provided about the accommodation process at Charles River.


About Biologics Testing Solutions
With more than 50 years of experience and proven regulatory expertise, the Charles River Biologics group can address challenging projects for biotechnology and pharmaceutical companies worldwide. Offering a variety of services such as contamination and impurity testing, protein characterization, bioassays, viral clearance studies and stability and lot release programs, we support clients throughout the biologic development cycle, from the establishment and characterization of cell banks through preclinical and clinical studies to marketed products. Whether clients need stand-alone services, a unique package of testing, or insourced support, our Biologics group can create a custom solution to suit their needs.  Each year more than 20,000 biologic testing reports are sent each and over 200 licenses products are supported by our biologics testing solutions team.

About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 18,000 employees within 100 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. 

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of >80% of the drugs approved by the FDA for the past 3 years.

Equal Employment Opportunity
Charles River Laboratories is an Equal Opportunity Employer - M/F/Disabled/Vet.

If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.


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