Senior Scientist - Protein Sciences

Req ID:  118452

Saffron Walden, GB, CB10 1XL

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Job Summary

Charles River are looking for an experienced, enthusiastic and highly motivated protein scientist, ideally with experience in the application of structural biology to drug discovery to join our new Structural Biology team at Chesterford Research Park.  This is an excellent opportunity for a successful candidate to play an influential role in shaping the drug development programs in close collaboration with our clients. Working across multiple disciplines CRL Early Discovery scientists have helped deliver over 80 pre-clinical candidates.  As part of a team at a world leading CRO, you will be investigating a wide range of therapeutic disease areas, target classes and various therapeutic modalities.  We are looking for top candidates who will have the opportunity to work and further career develop within our collaborative and fast paced dynamic CRO environment. 
Main Duties and Responsibilities
Working as part of a multidisciplinary team, you will be responsible for protein production, characterisation and crystallisation to support both large and small molecule projects across our therapeutic areas and, in collaboration with project teams, present critical data to clients. The role is lab-based and delivery focused and requires the ability to independently develop rational experiments and trouble shoot when required.  Dependent on experience, other responsibilities will include project management and key client contact roles.

Essential Requirements

  • Ph.D or equivalent experience with a central element of protein production for structural-based or protein-focussed programmes 
  • Extensive experience of construct design, protein expression and protein purification of multiple protein classes. 
  • Experience of protein expression from a range of expression systems (e.g. E.coli, insect cells, mammalian or yeast systems).
  • Expert in protein purification using a range of chromatographic techniques. 
  • Experience of crystallisation using commercially-available wide screens and targeted screens 
  • Evidence of ability to work effectively on concurrent projects within multi-disciplinary teams and able to adjust to quickly changing priorities
  • Excellent communication skills with effective presentation of work and data to project teams and clients
  • Ability to problem solve, work independently and deliver to deadlines
  • Evidence of strong interpersonal skills and collaborative approach to interact effectively with a wide range of colleagues and stake holders.


Desirable Requirements

  • Experience of application of protein-focussed biophysical techniques (e.g. NMR, SPR, DSF, ITC)
  • Experience of protein biochemistry in drug discovery programmes, e.g. assay development 
  • Experience of crystallographic methods to generate structures


All applicants must have existing right to work in the UK before being considered. 


About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 350 patents and 80 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.


About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 14,000 employees within 80 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2018, revenue increased by 22% to $2.27 billion from $1.86 billion in 2017.

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2018.