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Senior Scientist - Cell-Based Assay Development for Large Molecule Characterisation

Req ID:  39315
Location: 

Saffron Walden, ESS, GB, cb10 1xl

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Role

 

We are looking for a keen and enthusiastic lab-based scientist to work in our Integrated Biology team at our Saffron Walden site.  The jobholder will play an important role in early drug development for both large and small molecule programmes. Specifically, the role will be within the Integrated Biology team with responsibilities for developing and performing in vitro cell-based assays (e.g. reporter, proliferation, second messenger, binding, etc) and effector function assays to characterise novel large molecule drug discovery targets.   This position requires a dynamic, flexible person with great communication and presentation skills. Knowledge of immunology would be advantageous.

 

Candidate profile

 

You will have a minimum of a BSc (Hons), or equivalent, with several years’ relevant experience, preferably gained in an industrial setting or via a PhD, and be competent in the following areas:

 

  • Hands-on experience of developing and optimizing novel cell-based assays for the characterization of large molecule drug discovery targets.  Experience of developing cell-based assays for screening and profiling small molecules would be desirable.
  • Routine operation of cell-based assays including binding and enzymatic assay techniques to support characterisation of novel protein therapeutics.
  • Practical experience of performing
    • effector function assays (e.g. ADCC, CDC).
    • a wide range of assay formats including HTRF, ELISA, MSD and luminescence based formats.
    •  building assays using primary, clonal and recombinant cell lines.
  • Day-to-day problem solving, work prioritisation, and co-ordination across the team and other groups to ensure study and project requirements are met to timelines.
  • Data processing, tabulation and interpretation of results from cell characterisation and cell-based/binding assay work.
  • Strategic involvement in and managing of scheduling, operational and maintenance duties required within the laboratory.
  • Review and approval of study data, drafting appropriate protocols, reports and process documents as required.
  • Clear and confident communicator and have the ability to interpret and present your data to both your immediate project team and in wider client meetings.
  • Practical experience of flow cytometry based assay development and/or analysis would be desirable.

 

Main Tasks

 

  • To plan and carry out laboratory work in order to meet scientific program specifications.
  • Analyze, interpret, and quality control data to meet program specifications
  • Write up lab book to patent-acceptable standard
  • Confidently present own work in internal meetings and to the client via teleconference or videoconference
  • Use appropriate scientific literature to design & execute experiments
  • Work independently and solve problems on a day-to-day basis on own work and assist junior colleagues
  • Highlight interesting biology papers for the project team
  • Develop awareness of laboratory techniques and practices and significant scientific developments directed towards drug discovery
  • Attend appropriate training sessions as identified with the support of line manager
  • To operate in a safe manner at all times and to comply with CRL site-based guidelines
  • To work within the framework of the Charles River core values of Collaborate, Lead, Own, Care

 

 

About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 320 patents and 74 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.

 

About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

 

With over 13,000 employees within 80 facilities in 23 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges.  Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world.

 

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of 80% of the drugs approved by the FDA in 2017.

 

For more information, please visit www.criver.com.