Senior Scientist - CADD/Machine Learning

Req ID:  177412

Saffron Walden, GB, CB10 1XL Harlow, GB, CM19 5TR

For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Job Summary

We have an exciting new opportunity for a talented, dynamic scientist with an interest in both traditional computational chemistry techniques and machine learning/AI to join the CADD group at our drug discovery facilities in either Saffron Walden or Harlow, UK. This is an opportunity for you to develop a deep understanding of drug discovery whilst helping to influence and drive the growth of Charles River’s machine learning/AI offering through the design and implementation of machine learning tools to accelerate drug discovery. 


In this role you will work with a diverse range of organisations across the globe, from charitable organisations and academic groups to biotech and big pharma, and you will have the opportunity to work with world class scientists in different disciplines from across the wider Charles River organisation. As a senior scientist within the Early Discovery CADD team, you will be exposed to a wide range of drug discovery projects across different therapeutic areas and target classes at all stages of the drug discovery process.


Charles River has a strong culture of personal development, and you will have access to a wide range of training opportunities, with good potential for advancement in this key area of future development within an expanding organisation.


•    Provide computational chemistry support to client projects, working as part of high-performing, multi-disciplinary teams at Charles River. Occasionally you may also provide standalone computational chemistry support to clients.
•    You will support the drug discovery process at Charles River through working with the current group to expand the use of existing machine learning tools, and by designing and implementing new solutions to help scientists to best utilise their data to make better decisions faster.
•    Apply your expertise to help drive the progression of drug discovery programs at all stages of the drug discovery process, from hit finding through to the identification of pre-clinical candidates.
•    Accountability for presenting your work to Charles River’s client project teams and will interact directly with client team members in meetings and, when appropriate, during 1:1 discussions.
•    You will be involved in the growth and development of the CADD group, for example through identifying and implementing relevant new technologies in order to enhance CADD and medicinal chemistry capabilities.
•    You will have the opportunity to contribute to business development activities, including the writing and presentation of proposals for potential clients.

Profile and Requirements

•    A first degree or equivalent in chemistry or a closely related subject.
•    A PhD in a field of relevance to molecular modelling.
•    Postdoctoral experience applying computational chemistry to drug discovery related projects.
•    A keen interest in data science and machine learning/AI, combined with evidence of good programming skills, particularly python. A proven ability to take an idea and translate it into a working product would be an advantage.
•    A familiarity with cheminformatics toolkits and/or experience of working with relational databases would be an advantage.
•    A dynamic and flexible approach towards achieving client-based objectives, with the ability to deliver on multiple projects simultaneously and meet challenging deadlines.
•    Excellent interpersonal, communication and presentation skills. 
•    Exceptional problem-solving skills, sound scientific judgement and high quality decision making. An understanding of the statistics that are relevant to machine learning/AI would be an advantage
•    Models the Charles River Values of Care, Lead, Own and Collaborate.

About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 350 patents and 80 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.


About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.


With over 20,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. 


At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2021.


At Charles River Laboratories, we recognize and recruit all talent. We are a company committed to the principle of diversity and inclusion and work daily in this direction.