Senior Scientist - Antibody Engineering

Req ID:  109112
Location: 

Saffron Walden, GB, CB10 1XL

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Job Summary

We are looking to expand our large molecule discovery capabilities and have an exciting new opportunity for an enthusiastic scientist with experience of antibody engineering. This is a senior scientific role which is largely lab based and provides an opportunity to initiate and influence the development of the antibody engineering and formatting platform. The position sits within the Protein Science, Structural Biology and Biophysics group, at our drug discovery facilities in Saffron Walden, Essex, UK.  


The ideal candidate will have a degree or PhD level qualification in the field of Molecular biology or a related disciple together with several years’ proven experience in the field of antibody engineering. You will also have a good understanding of the structure and function of antibodies and antibody formats.

 

Key Knowledge/Skills
•    Knowledge of antibody engineering strategies for optimisation, humanisation, Fc engineering and sequence liabilities corrections
•    Experience of designing and cloning various antibody formats (VHH, scFv, Fab, full length, bispecific) into microbial and mammalian expression vectors
•    Strong background in molecular cloning techniques including DNA and RNA extraction, PCR, restriction enzyme digest and site directed mutagenesis
•    Expertise in DNA analysis and interpretation 
•    Strategic thinking in science and technology to build platform which will positively influence our biologics drug discovery pipeline
•    Excellent interpersonal, communication and presentation skills with the ability to coach and mentor more junior scientists as well as positively influence project direction and strategy
•    Ability to work as part of a multi-disciplinary team, with the flexibility required to work in a goal-oriented environment

 

Desirable:
•    Experience of novel fragments or scaffolds, ADC, site specific conjugation and linker optimisation
•    Practical experience in E.coli, insect cell and/or  mammalian platforms for antibody or recombinant protein expression for use in the Early Discovery portfolio
•    Practical experience with AKTA FPLC purification systems and track record of purifying multiple target families 
•    Analytical characterisation experience across SPR, HPLC-SEC, SEC-MALS methodologies
•    Experience operating with external clients, including resources and budgeting

About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 350 patents and 80 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.

 

About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

 

With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increased to $2.62 billion.

 

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2019.