Senior Scientist - Computational Chemistry

Req ID:  38742

Saffron Walden, ESS, GB, CB10 1XL

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.



No two days are ever the same in our fast paced environment and by joining our CADD team you will very quickly develop a deep understanding of drug discovery, experience a broad portfolio of targets & projects and influence our scientific partners.  At Charles River we care deeply about personal development and you will grow within our organisation through a wealth of opportunities which are hard to find elsewhere.


We have an exciting opportunity for a talented, dynamic Computational Chemist to provide scientific excellence within the CADD team, at our drug discovery facilities near Cambridge, UK. This position will see you providing computational expertise to impact upon integrated drug discovery programs and dedicated computational projects.


Main responsibilities

•             To drive project progression by providing computational chemistry expertise within drug discovery projects, working as a valued member of high performing multi-disciplinary teams

•             To maintain current awareness of latest computational techniques and practices, identifying opportunities and introducing new technologies into the CADD team

•             Occasionally contribute to business development activities


Key requirements

•             A first degree or equivalent in chemistry or a closely related subject

•             A PhD in a field of relevance to molecular modelling

•             Postdoctoral experience with significant exposure to the pharmaceutical industry

•             Excellent interpersonal, communication and presentation skills

•             A dynamic and flexible outlook with the ability to prepare high quality scientific documents to challenging deadlines

•             Experience in structure, ligand based and data based approaches in providing creative solutions to progress projects with an emerging track record of impacting upon projects

•             A sound knowledge of commercial molecular modelling software, data visualisation and pipelining tools

•             Expertise in molecular simulation or predictive technologies would be an advantage


About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 320 patents and 74 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.

About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 11,000 employees within 70 facilities in 18 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges.  Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2016, revenue increased by 23.3% to $1.68 billion from $1.36 billion in 2015.

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~70% of the drugs approved by the FDA in 2016.

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