Scientist/Senior Scientist - Protein & Antibody Generation

Req ID:  126275

Saffron Walden, GB, CB10 1XL

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Job Summary

Charles River are looking for an enthusiastic and highly motivated protein scientist, ideally with experience in the provision of various antibody formats to join our new team focussed on Large Molecule Drug Discovery at Cambridge, UK.  This is an excellent opportunity for a successful candidate to play an influential role in shaping the drug development programs in close collaboration with our clients. Working across multiple disciplines CRL Early Discovery scientists have helped deliver over 80 pre-clinical candidates.  


As part of a team at a world leading CRO, you will be investigating a wide range of therapeutic disease areas, target classes and various therapeutic modalities.  We are looking for top candidates who will have the opportunity to work and further career develop within our collaborative and fast paced dynamic CRO environment.


Main Duties and Responsibilities
Integrated into our expanding multi-disciplinary Structural Biology team, you can help discover the drugs of tomorrow.  You will be foundational in helping to develop our in-house large molecule discovery capabilities in a role with real opportunities for personal and career development.  The role is delivery focused and shall have responsibility for generation of various antibody formats (antibody formats (VH, scFvs, Fabs, full length, bispecific) plus a wide family of protein targets. Additionally, it would be very advantageous to have experience in antibody and protein characterisation (Biacore, SEC-HPLC, PAGE).  


Essential Requirements
•    Experience of mammalian expression of antibodies and other protein targets over a range of cell lines
•    Experience of antibody and other protein targets purification (Affinity and Size Exclusion chromatography), preferably on AKTA platform.
•    Scientific curiosity with a keenness to learn and self-develop with in the Structural Biology team


Desirable Requirements
•    Experience of antibody generation at medium to high throughput in an industrial environment.
•    Expression of wider protein expression using alternative expression hosts, purification methodologies and analytical protein characterisation techniques would be advantageous.
•    Experience of Biacore, SEC-HPLC and PAGE analysis.

About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 350 patents and 80 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.


About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.


With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increased to $2.62 billion.


At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2019.