Principal Technician - Analytical

Req ID:  159116

Saffron Walden, GB, CB10 1XL

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Job Summary

Charles River is seeking an exceptional, ambitious, innovative, and highly motivated lab-based analyst to work within the Purification Sciences team at our Saffron Walden site, analysing and purifying a diverse range of Medicinal Chemistry small molecules to advance drug discovery projects for our clients.


•    Provide analytical and purification support for medicinal chemists across multiple sites.
•    You will use your troubleshooting and problem-solving expertise to ensure instrument issues do not delay client projects. 
•    You will be involved in the development of new technologies within the Purification Sciences team.
•    You will interact with client project teams and be a point of contact for one or more projects.
•    With a keen interest in continuous improvement, you will have the opportunity to identify and implement workflow improvements. 
•    Training of less experienced team members. 


Candidate profile
We are seeking a Principal Technician who will have several years industrial experience within the field of chromatography. You will be educated ideally to a degree level in a related discipline and have demonstrated a drive for applying technical expertise to troubleshooting chromatography and workflow challenges. Adept in working as part of a multi-disciplinary team, you will need to possess the flexibility required to work in a goal-oriented environment, as well as:

•    A laboratory based practical background with significant experience using and developing automated purification protocols and/or other analytical chemistry techniques including UPLC/ HPLC/ SFC/ MS/ NMR instrumentation. Experience of; MassLynx, Chemstation, Chromscope and/or Trilution would be advantageous. 
•    Excellent communication skills: these will be essential to engage our customers and colleagues whilst working in a matrix environment.     
•    Ability to work well under pressure, independently and to tight deadlines. 
•    Strong organization and time management skills alongside an inbuilt flexibility to adapt to change.
•    A track record of dynamic workload prioritisation, problem solving and multitasking.
•    Identifying new technologies and creative approaches to drive forward effectiveness at a department level. 
•    To operate in a safe manner always and to comply with CRL site-based guidelines.
•    To work within the framework of the Charles River core values of Collaborate, Lead, Own, Care

About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 350 patents and 80 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.


About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.


With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increased to $2.62 billion.


At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2019.