Principal Scientist - Crystallography

Req ID:  141675

Saffron Walden, GB, CB10 1XL Harlow, GB, CM19 5TR

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Job Summary

Charles River has opportunities for Principal Crystallography Scientists within the Structural Biology and Biophysics team at Cambridge, UK.  Successful candidates will play an influential role in shaping our drug development programs in close collaboration with our clients. We work in a matrix environment throughout the Early Discovery portfolio, where you will gain experience across a wide range of therapeutic disease areas, target classes and various therapeutic modalities.  We are looking for exceptional candidates who would be driven by a fast paced and dynamic CRO environment.


Main Duties and Responsibilities:
Working as part of the multifunctional team, you will be responsible for providing key structural information to advance our Drug Discovery projects and, in collaboration with project teams, present critical data to clients.  The role is delivery focused and requires the ability to independently develop rational experiments and approaches for trouble shooting.  


Leading by example, you will also support and mentor team members as required.  Other responsibilities will include structural project management and a primary contact role with our clients. The successful candidate will be instrumental within the Structural and Biophysics team in influencing and developing the crystallography discipline.


Essential Requirements:
•    Ph.D or equivalent experience with track-record of delivering structural projects (i.e publications, PDB depositions)
•    5+ years industrial experience within drug discovery programs and proven track record of solving protein-ligand / fragment structures independently
•    Experience of protein crystallisation and trouble shooting
•    Ability to work effectively on multiple projects within multi-disciplinary teams.
•    Excellent communication skills with effective presentation of work and data to project teams and clients
•    Ability to problem solve, work independently and deliver to deadlines


Desirable Requirements:
•    Experience of biophysical techniques (SPR, DSF, ITC, NMR) 
•    Experience with Cryo-EM (data collection/processing)
•    Project management
•    Experience of protein expression (E.coli, insect cells or mammalian) and purification using ATKA FPLC systems
•    External client exposure

About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 350 patents and 80 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.


About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.


With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increased to $2.62 billion.


At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2019.