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Group Leader - CADD

Req ID:  44157

Saffron Walden, CAM, GB, CB10 1XL

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

We have an exciting new opportunity for a talented, dynamic Computational Chemist to provide scientific and managerial leadership within the CADD team, at our drug discovery facilities in Saffron Walden, UK.


In addition to management, mentoring and scientific development of scientists within the CADD team this high profile Client facing role will see you working with a diverse range of global organisations providing computational expertise to impact upon integrated drug discovery programs and dedicated CADD projects.  You will be a positive role model within our organisation influencing scientific strategies across disciplines. 


Main responsibilities

  • To provide managerial leadership within the CADD team, with responsibility for performance management, goal setting, providing feedback, motivating and developing staff
  • CADD leadership within integrated projects using expertise and skills to influence project direction and strategy
  • Project leadership of CADD standalone projects, delivering on objectives, managing resources, finance and client communication 
  • Act as CADD lead within business development activities preparing proposals and presenting to prospective clients
  • To provide broader scientific leadership, contributing and leading cross departmental projects and helping define future scientific direction
  • To identify and implement new technologies to enhance capabilities within CADD and medicinal chemistry
  • Promote high scientific visibility of Discovery capabilities internally and externally


Key requirements

  • A first degree or equivalent in chemistry or a closely related subject
  • A PhD in a field of relevance to molecular modelling
  • Excellent interpersonal, communication and presentation skills
  • Experience in managing, developing and mentoring
  • Extensive CADD experience within a drug discovery environment
  • A dynamic and flexible approach towards achieving client-based objectives and demonstrable ability to deliver on multiple simultaneous projects with challenging deadlines
  • Expertise in structure, ligand based and data based approaches with an extensive track record of impacting upon projects
  • In depth knowledge of commercial molecular modelling software, data visualisation and pipelining tools
  • Medicinal chemistry knowledge ideally across a range of target families


About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 350 patents and 80 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.


About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 14,000 employees within 80 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2018, revenue increased by 22% to $2.27 billion from $1.86 billion in 2017.

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2018.