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Director Large Molecule Discovery

Req ID:  39535

Saffron Walden, ESS, GB, cb10 1xl

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Director Large Molecule Discovery

Job Purpose


A key member of the senior biology team, and sitting across all major therapeutic areas, providing strong scientific and strategic leadership to all current and future large molecule projects.  This position will be key to building the CRL early discovery capabilities initially in Antibody projects but eventually covering all large molecule modalities. In addition to providing significant scientific input to expand the depth and breadth of the scientific relationship with current and new partners, the position will ensure there is seamless communication and transition of projects across disciplines internally, identification and implementation of cross-site/cross-functional activities in support of new or on-going programs and working with other members of the Project Teams and therapeutic area teams to identify additional ways of expanding current partnerships.

In addition to the activities mentioned above, this person will also be involved in aiding Business Development activities to identify new integrated Partners and collaborations. These activities will include meeting potential collaborators and preparing scientific proposals and presentations which outline our large molecule capabilities and expertise.


Main Tasks


  1. Play a key role within the biology team  to facilitate the attainment of business goals and objectives
  2. Working within the biology team this new position will play a key role in helping to build the CRL large molecule capabilities based initially on Antibody drug discovery but also moving to other modalities
  3. Work with the existing and new project teams to provide greater scientific depth that currently exists and proactive input into problem solving and project progression with clear and timely decision making to ensure projects deliver as the partner expects
  4. Consider potential new opportunities for existing relationships from reviewing the literature and sharing scientific interests in partner face to face meetings
  5. Mentor the PL and senior scientists within the project team based on their experience and background
  6. Facilitate cross-site involvement in projects as required (ie highlighting where within CRL studies could be performed that are needed by projects)
  7. Collaborate in scientific proposal generation for integrated projects including site visits and proposal presentation
  8. Maintain an up to date understanding of scientific developments within all aspects of large molecule biosciences and use this knowledge to further existing relationships and suggest scientific ideas for new collaborative relationships. To promote high scientific visibility of CRL large Molecule Discovery capabilities within CRL and externally
  9. To promote high scientific visibility of CRL Discovery capabilities within CRL and externally
  10. To contribute as required to the scientific due diligence of potential M&A targets




Internal:   Reporting to Executive Director, Biology; Working with other Disease Area Experts, Biology Directors, Group Leaders; Head of Chemistry/CADD, Chemistry Directors, Group Leaders;  ADME, DMPK Directors, Group Leaders; Structural Biology Directors Group and Team Leaders; In vivo Pharmacology Site Heads and Research Directors, Group and Team Leaders; Business Development  and Client Services teams.

External:  Partner JSC members and project leaders.


About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 320 patents and 74 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.


About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.


With over 13,000 employees within 80 facilities in 23 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges.  Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world.


At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of 80% of the drugs approved by the FDA in 2017.


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