Scientist, Antibody Discovery and Engineering

Req ID #:  92534

S. San Francisco, CA, US, 94080

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Job Summary

Duties and Responsibilities:

• Candidate will be supporting the antibody discovery group

• Design and execute antibody discovery campaigns including phage display and yeast display approaches

• Design and generate libraries for antibody engineering projects ranging from affinity maturation and humanization to dual-specific antibodies

• Apply deep sequencing (NGS) and bioinformatics for antibody engineering

• Initiate and support platform improvements 

• Record experiments and results, including analyzing, interpreting, and presenting data to the rest of the company

• Work collaboratively on timeline-driven projects 

Job Qualifications


• Requirements for this position include an MS with 7+ years or PhD with 4+ years of relevant hands-on experience (preferably in industry) in biochemistry, molecular biology, protein engineering or related field

• Must have experience with antibody phage display

• Experience with yeast display is a plus  

• Must have strong expertise in wide range of molecular biology techniques including mutagenesis, molecular cloning, construct design and sequence analysis 

• Experience in Protein engineering techniques, including, protein expression and purification, protein interaction characterization is a plus

• Experience with NGS is a plus 

• Detail-oriented, strong skills in organization, time management, communication and teamwork are essential.

• The candidate is expected to contribute at the bench as well as at strategic levels, and present data to project teams

About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 320 patents and 74 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.


About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.


With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increased to $2.62 billion.


At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2019.


Equal Employment Opportunity

Charles River Laboratories is an Equal Opportunity Employer - M/F/Disabled/Vet.


If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.


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Nearest Major Market: San Francisco
Nearest Secondary Market: Oakland

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