Research Scientist 1 - DMPK Bioanalytical

Req ID #:  106511

S. San Francisco, CA, US, 94080

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Job Summary

We are seeking a highly motivated, experienced Research Scientist 1 - DMPK Bioanalytical for our growing Discovery site located in South San Francisco, CA.


Serve as scientific team member conducting routine analysis of small molecules and biotherapeutics in complex biological matrices. Responsible for providing quantitative analysis, developing new analytical methods and data interpretation of various biological samples using LC-MS/MS and enzyme-based immunoassays.


Specific Responsibilities will include:

  • Develop, perform, and troubleshoot bioanalytical laboratory experiments, tests, and procedures 
  • Function as the primary contact for the planning and execution of Sponsor interaction related to research and method development, and for the design, scheduling, conduct and reporting of studies.
  • Ensure raw data is accurate, complete and in appropriate order to meet protocols and SOP specifications. 
  • Prepare high quality final reports appropriate for the study including method development, qualification, and sample analysis reports.
  • Assist with the oversight of the laboratory and mentor junior staff in areas such as protocol interpretation, method development and refinement, study-related problem resolution, and technique validation.  
  • Perform troubleshooting on analytical instrumentation including chromatography and mass spectrometry systems.
  • Aid in the development and communication of departmental systems, SOPs, policies, and procedures. 
  • May attend and present at scientific meetings. 
  • Perform all other related duties as assigned.  


Successful candidates in this position will:

  • Very strong analytical, troubleshooting and problem-solving skills
  • Capable of designing experiments, generating data and interpreting results independently
  • Able to provide basic level of leadership to junior research associates
  • Demonstrated success in applying independent scientific judgment in experimental design and analysis
  • Strong interpersonal skills and demonstrated ability to work collaboratively in a team environment with colleagues at various levels
  • Excellent organizational skills with attention to details
  • Understand the importance of project timelines and be objective driven
  • Understand general laboratory management and laboratory safety

The following are minimum requirements related to the Research Scientist 1 - DMPK Bioanalytical position.

  • Education: Bachelor's degree (B.S./B.A.) or equivalent in a scientific related discipline. Related Master's degree (M.S./M.A.) or Ph.D. preferred.
  • Experience:  Minimum of 6 years related experience in the contract research, academic, or pharmaceutical industry. Minimum of 3 years of theoretical and hands on experience with mass spectrometry and liquid chromatography is essential. Experience with enzyme-based immunoassays and/or protein chromatography is an asset.
  • An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above.
  • Other:  Strong analytical, troubleshooting and problem-solving skills. Effective written and verbal communication skills. Ability to handle multiple projects, prioritize work and meet deadlines. Proficiency in the use of standard software including Microsoft® Excel, Word, PowerPoint, etc. and analytical instrumentation software

About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 320 patents and 74 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.


About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.


With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increased to $2.62 billion.


At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2019.


Equal Employment Opportunity

Charles River Laboratories is an Equal Opportunity Employer - M/F/Disabled/Vet.


If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.


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Nearest Major Market: San Francisco
Nearest Secondary Market: Oakland

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