Pharmacology Group Leader

Req ID:  71132

Portishead, GB, BS20 7AW

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Job Summary

We have an opportunity for a motivated and pro-active individual to join the team at the Charles River Laboratories Portishead site in the UK. The site is focussed on providing state of the art cell biology and pharmacology support to a range of global pharmaceutical and biotechnology companies in areas including immune-oncology, autoimmune and inflammatory diseases, vaccine research and infection. We work on projects from early drug discovery through to clinical trials.


The successful applicant will take up a scientific management role within the company, directly supporting the Senior Leadership as well as interacting with Group Leaders and Managers in charge of synergistic activities. They will work directly with our Client Services and Business Development staff supporting the generation of proposals for individual studies and wider programs of work, as well as our customers providing project management to ongoing work. Main tasks include study design, data analysis, report writing and record keeping to high quality standards.


As a line manager, the individual will supervise a team of in vivo technicians and scientists, playing a key role in their development, identifying training needs and opportunities, as well as offering coaching and leadership.


As a project manager, the post-holder will be responsible for the delivery of multiple, often complex and multi-disciplinary studies. They will work closely with project management and operational staff.


As a Home Office Project Licence holder, the individual will be responsible for ensuring compliance with strict regulations surrounding the conduct of in vivo studies, in conjunction with others with formal roles in this space (NACWO, NVS, PEL holder, etc).


Because Charles River is a CRO working to high quality standards, there is also a large onus on all personnel to maintain accurate records and have a high standard of report writing.


Essential Requirements

  • A high level of scientific understanding in areas of immunology and inflammation with relevance to drug discovery and development.
  • A PhD or significant experience in pharmacology, immunology or a related discipline.
  • Experience of working with in vivo efficacy models.
  • An ability to work on multiple projects and with multiple teams in order to deliver to a high quality in a timely fashion.
  • Experience in leading teams of staff, supporting their development and getting the most from the skills that they have to offer.
  • Holder (current or past) of a Home Office Personal License under the Animals (Scientific Procedures) Act 1986, Modules 1-4.
  • Good record keeping, data analysis and report writing skills.
  • Experience of working in a commercial environment to quality standards. Experience of working in a teamwork focused environment with a flexible attitude to working hours.
  • Expertise in computer software and statistical analysis especially in relation to the powering of experiments.



  • Direct experience of the wider aspects of pharmacology and drug discovery and development.
  • Direct experience working in a Contract Research environment.
  • Direct experience in working with regulatory bodies, such as the Home Office, HSE, etc.

About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 350 patents and 80 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.


About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.


With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increased to $2.62 billion.


At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2019.