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Manager (Flow Cytometry)

Req ID:  44609
Location: 

Portishead, BST, GB

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Manager - Flow Cytometry

 

We have an opportunity for a motivated and pro-active science manager to lead a flow cytometry scientific team at the Charles River Laboratories Portishead site in the UK. The successful applicant will lead and manage a state of the art flow cytometry team to service a variety of in vitro and ex vivo studies (pre-clinical and clinical) across the site.  There will be ample scope for the individual to run projects, develop new assays and thereby expand the repertoire of expertise within the team.

 

The Portishead site is focussed on providing state of the art cell biology and pharmacology support to a range of global pharmaceutical and biotechnology companies in areas including immuno-oncology, autoimmune and inflammatory disease and infection. We work on projects from early drug discovery through to clinical trials.

 

The post holder will manage a central flow cytometry service within the analytically services team and be a focal point for flow cytometry and FACS sorting support on site.  They will advise other scientists on best practice in panel design through to analysis.  The post-holder will create an environment of flow cytometry excellence; will track, monitor, run and improve flow cytometry processes and procedures, and liaise with engineers.  There is also the potential to collaborate with other Charles River sites.  The post holder will work on exciting novel treatments for human diseases, making a genuine contribution to moving potential new drugs into the clinic.


Requirements:

Extensive experience of developing, optimizing and trouble-shooting flow cytometry of human and/or murine immune cell subsets is essential, including complex cell surface and intracellular marker panels.

Experience of FACS sorting cell populations, is essential.

Experience of Diva and Flowjo software is essential.

Line Management and Project Management experience.

Strong background in Immunology and a good command of biomedical sciences.

Ideally a Master’s degree or PhD although other experienced candidates will be considered.

Some experience in developing, optimizing and executing biological assays ideally in a pharma or biotech setting would be an advantage.

Highly organised with an ability to plan own day to day activities within given work programme with agreement of manager.

Capable of expressing technical information/views in an accurate and understandable way.

We are compliant to the ISO9001 standard, so all personnel have a responsibility to understand and follow the company’s quality management system, maintain accurate records and work to a high standard.

A clear grasp of the drug discovery process would be an advantage. 

Previous employment in the pharmaceutical or biotechnology industry would be an advantage.

An understanding of GCP/GCLP would also be an advantage.

 

About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 350 patents and 80 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.

 

About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 14,000 employees within 80 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2018, revenue increased by 22% to $2.27 billion from $1.86 billion in 2017.

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2018.