Principal Technician

Req ID:  44861

Portishead (Bristol), SOM, GB

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Principal Technician

We have an opportunity for a motivated and pro-active individual to join the scientific team at the Charles River Laboratories Portishead site in the UK. 


The site is focussed on providing state of the art cell biology and pharmacology support to a range of global pharmaceutical and biotechnology companies in areas including immune oncology, autoimmune and inflammatory disease and infection. We work on projects from early drug discovery through to clinical trials.


The successful applicant will be an integral part of a dynamic and flexible team that conducts a wide range of in vivo efficacy testing models as well as developing new in vivo models.  Techniques that would be used on a regular occurrence include animal handling, drug administration to rodents by a variety of routes, blood sampling, clinical assessment of disease and dissection.  There is also a large onus on all personnel to maintain accurate records. Appropriate training will be provided.



·       Holder of a Home Office Personal License under the Animals (Scientific Procedures) Act 1986.

·       Experience performing husbandry and regulated procedures

·       Experience working under the Code of Practice for the housing and care of animals used in scientific procedures.

·       Work within defined Standard Operational Procedures (SOPs) with a keen eye for detail.

·       Passion for working with animals and their welfare.

·       Experience handling animals and working under SPF conditions.

·       Experience administering substances by a variety of routes such as intranasal, intragastric, intraperitoneal, intravenous, topical and intramuscular.

·       Experience of schedule 1 killing and anaesthesia of small rodents.

·       Experience of blood sampling and dissection of small rodents.

·       A flexible attitude to working hours.

·       Be able to contribute to weekend and out of hours work on a rota basis

·       Ideally competence in data entry and excellent record keeping.

·       Ideally experience of additional laboratory techniques.

About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 320 patents and 74 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.


About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.


With over 13,000 employees within 80 facilities in 23 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges.  Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world.


At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of 80% of the drugs approved by the FDA in 2017.


For more information, please visit