Director, In Vitro Services (Immunology)

Req ID #:  81335

Morrisville, NC, US, 27560

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Job Summary

Oversee day to day operations of team responsible for tumor model inventory and implant material production, bioanalytical assay development and execution, and cancer immunology studies.  Support sustained growth of bioanalytical services through delivery of business quality and volume objectives and strategic leadership of capability development initiatives.

We are seeking a Director, In Vitro Services (Immunology) for our Discovery site located in Morrisville, NC.

The following are responsibilities related to the Director, In Vitro Services (Immunology):

Biological Reagents and Sample Management
•    Leader of team of scientists that develops and maintains registry of tumor materials including cell-lines and PDX material and other biological reagents used in cancer pharmacology studies.
•    Develop and maintain appropriate laboratory QA procedures and enforce adherence.
•    Manage adherence to best practice cell line banking and expansion strategies and record keeping.

Bioanalytical Assays and Immunology
•    Leader of team of scientists that develop and execute a wide variety of biological assays using in-vitro and ex-vivo samples in cancer pharmacology studies
•    Provide in-depth scientific guidance for experimental strategies to measure state-of-the-art biological endpoints and their response to experimental treatments; endpoints include cancer phenotypes, immune cell populations and activation states, gene expression, cell-cycle and signal transduction pathways.
•    Oversee project management activities such as scheduling of experiments, acquisition of materials, coordination with aligned groups for execution, and completion of data analysis and reporting.

Staff and Technical Development
•    Provide a culture of learning and development opportunity for scientific staff.  Instruct staff as needed in fields of cancer biology and cancer immunology.
•    Develop strategic plans for hiring to meet growing demand and changing technologies. Oversee hiring process and staff development through performance management and promotion.
•    Develop and oversee the implementation of departmental training programs, including orientation.

Business Development  
•    Participate in discussions with customers to represent capabilities and provide strategic guidance to achieve experimental goals.
•    Partner with designated client services representatives to ensure the production of timely, high quality research proposals.
•    Partner with project managers/study directors to effectively implement customer requested study changes and communicate progress.

The following are minimum qualifications related to the Director, In Vitro Services (Immunology) position:

Education:   Doctoral degree (PhD, DVM, MD) or equivalent in related discipline.
 Experience:  7 to 10 years experience in the contract research or pharmaceutical industry conducting scientific research in oncology. Postdoctoral experience preferred with demonstrated research capability as demonstrated by publications in peer-reviewed journals in related fields such as oncology and immunology. Extensive hands on experience in basic immunology in vitro techniques including flow cytometry, cytokine analysis, cytotoxicity and proliferation assays, etc.  Proficiency in DNA and RNA assays, protein immunoassay technologies, ELISAs, Luminex etc.  

About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 320 patents and 74 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.


About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.


With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increased to $2.62 billion.


At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2019.


Equal Employment Opportunity


<span style="font-family:"Arial",sans-serif">Charles River Laboratories is an Equal Opportunity Employer - M/F/Disabled/Vet.


<span style="font-family:"Arial",sans-serif">If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to <span style="font-family:"Arial",sans-serif"><span style="font-family:"Arial",sans-serif">. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications<span style="font-family:"Arial",sans-serif">.


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