Research Leader - Scale up Chemistry

Req ID:  44232
Location: 

Harlow, ESS, GB, CM19 5TR

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

 

 

Research Leader in Scale-up Chemistry

Due to our continued growth we have an exciting opportunity for individuals aiming to further develop their managerial skills in a fast-paced CRO environment.  We are looking for a dynamic, highly motivated Chemist to provide scientific leadership within the Scale Up Chemistry team at our drug discovery facilities in Harlow, Essex, UK.  In addition, this high-profile role will see you working with a diverse range of global organisations to support integrated drug discovery programmes and the transition of projects into early development and GMP manufacture.

 

Main responsibilities

  • To provide dynamic scientific leadership to project teams by designing, influencing and co-coordinating work plans, and using sound scientific decision making and creative problem-solving skills to achieve project goals.
  • Extensive expertise in the synthesis of key intermediates and APIs on the 10g -1kg scale, with the ability to trouble shoot and develop new routes from Medicinal Chemistry.
  • Conduct synthetic organic chemistry and to plan synthetic routes and perform literature searches to support on-going projects.
  • Act as subject matter specialist, advising integrated project teams on material supply strategy
  • To coordinate and transfer technical knowledge to third party GMP CROs.
  • To contribute to, and lead Business Development activities.

Key requirements

 

  • A first degree in chemistry or a closely related subject.
  • Extensive expertise in scientific leadership of teams and synthesis to help deliver late stage intermediates and APIs on the 10g -1kg scale: able to trouble shoot, develop new routes from Medicinal Chemistry and prepare technical transfer packages.
  • Exceptional problem-solving skills, sound scientific judgement and high quality decision making, which has impacted positively on project deliverables.
  • A positive role model with a ‘can-do’ attitude, who contributes to departmental goals, innovation and promotes best practice with strong evidence of interacting closely across disciplines.
  • Experience in motivating and developing others, e.g. mentoring of junior scientists
  • Excellent interpersonal, communication and presentation skills, as demonstrated both internally and externally with clients.
  • Business awareness skills to monitor project resources and finances within an acceptable budget, ideally gained in a CRO environment; contributions to Business Development proposals and face to face meetings.
  • A dynamic and flexible approach towards achieving client-based objectives, with developing strategic thinking.
  • Models the Charles River Values of Care, Lead, Own and Collaborate.
  • Must be able to work at Harlow, Essex, UK.

 

About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 350 patents and 80 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.

 

About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 14,000 employees within 80 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2018, revenue increased by 22% to $2.27 billion from $1.86 billion in 2017.

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2018.