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Research Leader - Scale up Chemistry

Req ID:  44232

Harlow, ESS, GB, CM19 5TR

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.



Research Leader in Scale-up Chemistry

Main responsibilities

Act as subject matter specialist, advising integrated project teams on material supply strategy

Extensive expertise in the synthesis of key intermediates and APIs on the 10g -kg scale, with the ability to trouble shoot and develop new routes from MedChem

Plan synthetic routes and perform literature searches to support on-going projects

Conduct synthetic organic chemistry at multi-gram to kilo scale using large scale equipment

Transfer of technical knowledge to third party GMP CMOs

To provide scientific leadership to project teams by designing, influencing and co-coordinating work plans, and using sound scientific decision making and creative problem solving skills to achieve project goals


Key requirements

A first degree in chemistry

Extensive expertise in the synthesis of key intermediate s and APIs on the 10g   kg  scale, with the ability to trouble shoot and develop new routes from Medicinal Chemistry

Excellent interpersonal, communication and presentation skills, as demonstrated both internally and externally with clients

Experience in motivating and developing others, e.g. mentoring of junior scientists

A positive role model with a ‘can-do’ attitude, who contributes to departmental goals and promotes best practice

Broad understanding of the drug discovery and development process

Strong track record of scientific impact in projects, as evidenced by publications and/or co-inventorship on multiple patent applications

Strong commercial awareness, ideally gained in a CRO environment

Experience of designing and coordinating chemistry work plans for others

Exceptional problem solving skills, sound scientific judgement and high quality decision making, which has impacted positively on project deliverables

Awareness of how project resources and finances are managed within an acceptable budget

A dynamic and flexible approach towards achieving client-based objectives, with developing strategic thinking

Ability to prepare high quality scientific documents to challenging deadlines

High quality contributions to Business Development proposals and face to face meetings



About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 350 patents and 80 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.


About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 14,000 employees within 80 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2018, revenue increased by 22% to $2.27 billion from $1.86 billion in 2017.

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2018.